About to load GB file from disk in Python on PYNQ

Hi, dear PYNQ elites,

In my application, it will ftp from PYNQ board to get the input file from the remote server. However, the file size will be 900MB around. Then, the Python SW code on PYNQ will open the file to read one line and then write to the input buffer of the HW accelerator on PYNQ until the end of the file. However, since the DRAM size of PYNQ is 512MHB, do you foresee if there has any potential issue in the application? Or any suggestion supposed that the file size cannot be reduced further?