The USB connection uses the RNDIS protocol (similar to a number of android phones) which doesn’t appear to be supported natively on MacOS. A quick search turned up HoRNDIS as a possible optional but it is not something I’ve tried
I did this in March 2019 briefly to test the USB Gadgets access from macOS (High Sierra).
By default, the File system Gadget and Serial port Gadget worked well, but the Ethernet Gadget did not come up.
In my macOS configuration, it required the installation of
HoRNDIS-9.2.pkg (46919 bytes) (md5sum 8207800ef89dc1bb0cca530e4ef39009; GPG signature). Improves support for devices including Nokia 7 Plus. This release was developed by Mikhail Iakhiaev, who is the current maintainer of HoRNDIS. This version only supports MacOS 10.11 and up.
Once installed and rebooted, I was able to ping 192.168.3.1 and to browse to the PYNQ Jupyter Notebook at that location as well.
Starting from macOS Sierra, the HoRNDIS kernel extension is supposed to have been installed, but several pages recommend reinstalling if it does not come up at once.