Hi Kevin,
Can you isolate whether it is the first or second line that is causing the crash. Put each line in its own cell then retry. I am more concerned about your 2nd line. I would not use a hard address like you have in that MMIO line. Instead take a look at how to use ol.ip_dict. Try that in its own cell and interrogate the dictionary and locate your gpio block. PYNQ gives you a driver for axi_gpio cores so if your module is a GPIO I would use that instead of the MMIO.
If in fact it was the first line reading the xsa file then we can try something else and isolate why the XSA is giving you issues.
Let me know what you find after those steps.
-Regards,
Nathan